The Anticancer Drugs PDF Download

The Anticancer Drugs PDF
Author: William B. Pratt
Publisher: Oxford University Press, USA
Size: 79.46 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 352
View: 2487

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This is an up-to-date review of the pharmacology, mechanisms of action, development of resistance, and toxicity of cancer chemotherapeutic agents. A rationale for their clinical use, based on cancer cell biology, is given for each class of drugs.

The Sv40 Replicon Model For Analysis Of Anticancer Drugs PDF Download

The SV40 Replicon Model for Analysis of Anticancer Drugs PDF
Author: Robert M. Snapka
Publisher: Elsevier
Size: 45.48 MB
Format: PDF, ePub
Category : Technology & Engineering
Languages : en
Pages : 193
View: 2411

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This book provides the most up-to-date review of the simian virus 40 (SV40) minichromosome as a model for the mammalian chromosome in studies of DNA replication. It focuses on disruption of DNA replication by anticancer drugs and DNA-damaging agents. There is a strong emphasis on the unique advantages of SV40 as an experimental system for the analysis of these classes of anticancer drug mechanisms. The new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication are covered in detail to aid readers in designing and interpreting similar experiments. Presents unique advantages of SV40 as an experimental system for the study of classes of anticancer drugs Details new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication Provides details to help the reader design and interpret similar experiments

Fate And Effects Of Anticancer Drugs In The Environment PDF Download

Fate and Effects of Anticancer Drugs in the Environment PDF
Author: Ester Heath
Publisher: Springer Nature
Size: 20.20 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 469
View: 6001

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The book provides current knowledge and research on the presence and effects of anticancer drug residues in the aqueous environment and covers all relevant aspects of the presence of these residues in wastewaters and natural aquatic systems, where numerous analogies between their pharmacokinetics and pharmacodynamics in humans and their effects in the environment can be drawn. This book comprises of 18 chapters and represents the combined work of leading scientists from different research institutions from across the globe. We present the state of the art in the field of anticancer drug residues in the aquatic environment while being cognizant of the many challenges that remain.

Preclinical And Clinical Modulation Of Anticancer Drugs PDF Download

Preclinical and Clinical Modulation of Anticancer Drugs PDF
Author: Kenneth D. Tew
Publisher: CRC Press
Size: 35.77 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 384
View: 2598

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Preclinical and Clinical Modulation of Anticancer Drugs focuses on the theoretical and practical approaches to designing and enacting modulation principles. Each class of anticancer drug and the different types of modulators used within each drug class are discussed within individual chapters. The molecular and biochemical rationale for the use of specific modulators is discussed in detail, and preclinical and clinical implications of the data are integrated into each chapter. Mechanisms of drug resistance and the reasons behind circumventing the resistant phenotype are covered. The book will interest cancer chemotherapists, pharmacologists, oncologists, biochemists, and experimental therapeutics researchers, in addition to students studying the principles of drug discovery and protocol design.

Organ Directed Toxicities Of Anticancer Drugs PDF Download

Organ Directed Toxicities of Anticancer Drugs PDF
Author: Miles P. Hacker
Publisher: Springer Science & Business Media
Size: 25.84 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 254
View: 888

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The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif ferentiate between normal and neoplastic cells, little selectivity exists in currently used oncolytic drugs. Consequently, significant toxicity to the patient is expected when systemic cancer chemotherapy is chosen as an appropriate therapeutic in tervention. Much of this toxicity, such as damage to the bone marrow, gastroin testinal tract, or hair follicles, is predictable based upon the fact that anticancer drugs kill actively dividing cells. These types of toxicities, while serious, are usually manageable and reversible and are, therefore, not often considered to be dose limiting. Unfortunately, several of the most important anticancer drugs also damage tissues in which the growth fraction is relatively small. Such toxicities can not be predicted based on the chemical structure of the drugs, are often not detected in preclinical studies, and are encountered frequently for the first time in clinical studies. Further, unlike most of the proliferative-dependent toxicities, the unpre dicted toxicities are usually irreversible or only partially reversible upon cessation of drug administration. Because of this, the unpredicted toxicities are referred to as dose limiting. They represent a significant barrier to the ultimate efficacy of several of our most important anticancer drugs.

Chemistry And Pharmacology Of Anticancer Drugs PDF Download

Chemistry and Pharmacology of Anticancer Drugs PDF
Author: David E. Thurston
Publisher: CRC Press
Size: 62.27 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 594
View: 3174

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While drug therapies developed in the last 80 years have markedly improved treatment outcomes and the management of some types of cancers, the lack of effectiveness and side effects associated with the most common treatment types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents and therapeutic approaches currently in use or in advanced stages of clinical trials, including biological-based therapies. The book is unique in providing molecular structures for all anticancer agents, discussing them in terms of history of development, chemistry, mechanism of action, structure–function relationships, and pharmacology. It also provides relevant information on side effects, dosing, and formulation. The authors, renowned scientists in cancer research and drug discovery, also provide up-to-date information on the drug discovery process, including discussions of new research tools, tumor-targeting strategies, and fundamental concepts in the relatively new areas of precision medicine and chemoprevention. Chemistry and Pharmacology of Anticancer Drugs is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists involved in the development of new anticancer therapies. Its breadth of coverage, clear explanations, and illustrations also make it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, dentistry, nutrition, the biomedical sciences, and related disciplines. Key Features: Summarizes the fundamental causes of cancer, modes of treatment, and strategies for cancer drug discovery Brings together a broad spectrum of information relating to the chemistry and pharmacology of all families of anticancer agents and therapies Includes up-to-date information on cutting-edge aspects of cancer treatments such as biomarkers, pharmacogenetics, and pharmacogenomics Features new chapters on the "Evolution of Anticancer Therapies", "Antibody-Based Therapies", and "Cancer Chemoprevention"

Anticancer Drug Development PDF Download

Anticancer Drug Development PDF
Author: Bruce C. Baguley
Publisher: Elsevier
Size: 34.19 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 397
View: 316

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Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Medicinal Chemistry Of Anticancer Drugs PDF Download

Medicinal Chemistry of Anticancer Drugs PDF
Author: Carmen Avendano
Publisher: Elsevier
Size: 72.51 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 400
View: 2070

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Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of new active structures. * Explains the biological basis of cancer treatment and the role of chemists in improving anticancer drugs * Provides the historical background and serves as a comprehensive and practical guide on cancer research and anticancer drug development * Includes coverage of different approaches to treating cancer, drug resistance, and a chapter on cancer prevention

Molecular Aspects Of Anticancer Drug Dna Interactions PDF Download

Molecular Aspects of Anticancer Drug DNA Interactions PDF
Author: Stephen Neidle
Publisher: CRC Press
Size: 74.75 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 336
View: 215

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This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.

The Japanese Pharmaceutical Industry PDF Download

The Japanese Pharmaceutical Industry PDF
Author: Maki Umemura
Publisher: Taylor & Francis
Size: 17.88 MB
Format: PDF, Docs
Category : Business & Economics
Languages : en
Pages : 208
View: 1326

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Charting the development of the industry from post-war devastation, through good recovery in the 1960s, and then up to the present, the book explores why Japan, despite being a world leader in many high technology industries, is only a minor player in the global pharmaceutical industry.

Targeting Of Drugs 6 PDF Download

Targeting of Drugs 6 PDF
Author: Gregory Gregoriadis
Publisher: Springer Science & Business Media
Size: 26.22 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 302
View: 1212

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Proceedings of a NATO ASI held in Cape Sounion Beach, Greece, June 24-July 5, 1997

Cancer Pharmacology PDF Download

Cancer Pharmacology PDF
Author: Ashkan Emadi, MD, PhD
Publisher: Springer Publishing Company
Size: 49.59 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 354
View: 2386

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Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon malignancies. Beautifully illustrated throughout, each chapter contains visually engaging figures detailing the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic, and molecular properties of the various agents, and their mechanisms of action. As the first illustrated book of its kind, this highly visual text uses a uniform approach to each cancer drug class and agent presented in the book, and covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Flow diagrams, clinical tables, and bulleted text further explain important information pertaining to each cancer drug class including their indications, mechanisms of action, potential adverse reactions, dosing and dose adjustments, and safety monitoring. Organized in an easyto- digest format and replete with detailed images, clinical pearls, and end of chapter Q&As, this evidence-based reference presents all major classes, agents, targets, and approaches to cancer pharmacotherapy. Whether you are a trainee, a clinical scientist, or a clinician in practice, the book is an ideal reference. It presents challenging information in an instructional way, illustrates key concepts for ease of retention, and poses tough questions so readers can problem solve potential scenarios and test their pharmacologic acumen. Written by leading experts in oncopharmacology, this first-of-its kind manual is a “must have” for anyone involved in the basic, translational, or clinical aspects of oncology and hematology including clinicians, pharmacists, nurses, and trainees. KEY FEATURES: In Includes visual depictions of chemical structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents Describes how chemotherapy, targeted therapy, immunotherapy, and hormonal therapy work and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other modalities Over 100 highly stylized images and numerous comprehensive tables Covers challenges related to drug development, drug approval, and regulatory issues in relation to anticancer treatments All chapters conclude with clinical pearls and detailed clinical Q&As with descriptive rationales Purchase includes access to the ebook for use on most mobile devices or computers