The Biophysical Chemistry Of Nucleic Acids Proteins PDF Download

The Biophysical Chemistry of Nucleic Acids   Proteins PDF
Author: Thomas E. Creighton
Publisher: Damaris Publishing
Size: 54.54 MB
Format: PDF, ePub, Docs
Category : Catalysis
Languages : en
Pages : 774
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DNA, RNA and proteins are undoubtedly the most important biological molecules. Being large macromolecules, their physical, chemical and biological properties can differ from those of the monomers from which they are made. This book describes their structures, origins and other key issues.

The Biophysical Chemistry Of Nucleic Acids PDF Download

The Biophysical Chemistry of Nucleic Acids PDF
Author: Thomas E. Creighton
Publisher:
Size: 66.45 MB
Format: PDF, ePub, Mobi
Category : Nucleic acids
Languages : en
Pages : 328
View: 2168

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The first chapter is a general introduction to the covalent structures and conformations of macromolecules. The remaining chapters deal with the nucleic acids. The structural and chemical properties of DNA are the basis of its central role in storing and transmitting the genetic information(Chapter 2). DNA molecules tend to be immensely long, equivalent to a rope that is many kilometers long, which gives them special topological properties that must be accommodated (Chapter 3). The structure of RNA differs from DNA only very slightly, but this gives it remarkably different properties and functions (Chapter 4). The abilities of individual strands of DNA and RNA to base-pair with other strands with complementary nucleotide sequences are central to many techniques of molecular biology and increasingly to molecular medicine (Chapter 5). The ability to manipulate nucleic acidsis central to molecular biology and described in Chapter 6.Central to the functions of proteins and nucleic acids is their interactions with other molecules, and some of the physiologically most important interactions are those between proteins and nucleic acids (Chapter 7). The most impressive and important property of proteins is their ability of catalyze the rates of chemical reactions by many orders of magnitude, and usually incredibly specifically; nucleic acids also share in this ability (Chapter 8).

Biophysical Chemistry Of Proteins PDF Download

Biophysical Chemistry of Proteins PDF
Author: Engelbert Buxbaum
Publisher: Springer Science & Business Media
Size: 21.52 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 510
View: 6469

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The book is structured in nine sections, each containing several chapters. The volume starts with an overview of analytical techniques and progresses through purification of proteins; protein modification and inactivation; protein size, shape, and structure; enzyme kinetics; protein-ligand interactions; industrial enzymology; and laboratory quality control. The book is targeted at all scientists interested in protein research.

Introduction To Biophysical Methods For Protein And Nucleic Acid Research PDF Download

Introduction to Biophysical Methods for Protein and Nucleic Acid Research PDF
Author: Jay A. Glasel
Publisher: Academic Press
Size: 66.51 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 510
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The first of its kind, Introduction to Biophysical Methods for Protein and Nucleic Acid Research serves as a text for the experienced researcher and student requiring an introduction to the field. Each chapter presents a description of the physical basis of the method, the type of information that may be obtained with the method, how data should be analyzed and interpreted and, where appropriate, practical tips about procedures and equipment. Key Features * Modern Use of Mass Spectroscopy * NMR Spectroscopy * Molecular Modeling and Graphics * Macintosh and DOS/Windows 3.x disks

Biophysical Chemistry PDF Download

Biophysical Chemistry PDF
Author: Alan Cooper
Publisher: Royal Society of Chemistry
Size: 53.50 MB
Format: PDF, ePub, Docs
Category : Biochimie physique
Languages : en
Pages : 184
View: 109

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This book will be ideal for early undergraduates studying chemical or physical sciences and will act as a basis for more advanced study.

Biophysical Chemical And Functional Probes Of Rna Structure Interactions And Folding PDF Download

Biophysical  Chemical  and Functional Probes of RNA Structure  Interactions and Folding  PDF
Author: Daniel Herschlag
Publisher: Academic Press
Size: 77.21 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 496
View: 6199

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This MIE volume provides laboratory techniques that aim to predict the structure of a protein which can have tremendous implications ranging from drug design, to cellular pathways and their dynamics, to viral entry into cells. Expert researchers introduce the most advanced technologies and techniques in protein structure and folding Includes techniques on tiling assays

Progress In Biophysics And Biophysical Chemistry PDF Download

Progress in Biophysics and Biophysical Chemistry PDF
Author: J. A. V. Butler
Publisher: Elsevier
Size: 67.71 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 352
View: 4030

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Progress in Biophysics and Biophysical Chemistry, Volume 12, provides an overview of the state of knowledge in biophysics and biological chemistry. The book begins with a study on cell division synchronization. This is followed by separate chapters on the biology and function of the nucleolus; the nature of ribosomes and their involvement in protein synthesis; taste receptor stimulation; and the various methods developed for quantitative estimation of the amount of dye deposited in a stained preparation as well as some of the associated theoretical and practical implications. Subsequent chapters deal with the preparation, fractionation, physical properties, analysis, and functions of histones; and the use of tritium labelled DNA precursors in autoradiography.

Biophysical Chemistry PDF Download

Biophysical Chemistry PDF
Author: Dagmar Klostermeier
Publisher: CRC Press
Size: 13.74 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 770
View: 7710

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Biophysical Chemistry explores the concepts of physical chemistry and molecular structure that underlie biochemical processes. Ideally suited for undergradate students and scientists with backgrounds in physics, chemistry or biology, it is also equally accessible to students and scientists in related fields as the book concisely describes the fundamental aspects of biophysical chemistry, and puts them into a biochemical context. The book is organized in four parts, covering thermodynamics, kinetics, molecular structure and stability, and biophysical methods. Cross-references within and between these parts emphasize common themes and highlight recurrent principles. End of chapter problems illustrate the main points explored and their relevance for biochemistry, enabling students to apply their knowledge and to transfer it to laboratory projects. Features: Connects principles of physical chemistry to biochemistry Emphasizes the role of organic reactions as tools for modification and manipulation of biomolecules Includes a comprehensive section on the theory of modern biophysical methods and their applications

Medicinal Chemistry Of Nucleic Acids PDF Download

Medicinal Chemistry of Nucleic Acids PDF
Author: Li-He Zhang
Publisher: John Wiley & Sons
Size: 75.91 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 448
View: 2095

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Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

Mass Spectrometry Of Nucleosides And Nucleic Acids PDF Download

Mass Spectrometry of Nucleosides and Nucleic Acids PDF
Author: Joseph H. Banoub
Publisher: CRC Press
Size: 35.43 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 504
View: 6797

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Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustrates the diversity of strategies employed in the characterization and sequencing of DNA and RNA oligomers, nucleosides, nucleotides, and adducts. It describes studies performed on deoxyinosine and its analogues and provides an introduction to tandem mass spectrometry (MS/MS). Next, the contributors examine mass spectrometric application in the study of cyclic nucleotides in biochemical signal transduction. They analyze urinary modified nucleosides and explore DNA adducts. They discuss isotope labeling of DNA-mass spectrometry (ILD-MS) and examine various uses of electrospray ionization mass spectrometry (ESI-MS). The book reviews recent progress in the direct MS characterization of noncovalent nucleic acid-protein complexes, explores the interaction and ionization of guanidine-derived compounds with highly acidic biomolecules, and examines quantitative identification of nucleic acids via signature digestion products detected using mass spectrometry. The book describes a direct-infusion ESI-MS approach that can serve as a screening technique for the presence of modified nucleosides from small RNAs. Lastly, it discusses the LC-MS/MS method for the in vitro replication studies on damage-containing DNA substrates, and concludes with an examination of the influence of metal ions on the structure and reactivity of nucleic acids. The exciting developments in mass spectrometry technology have fueled incredible advances in our understanding of nucleic acids and their complexes. The contributions presented in this volume capture the range of these advances, helping to inspire new findings and avenues of research.

Pharmaceutical Biotechnology PDF Download

Pharmaceutical Biotechnology PDF
Author: Daan J. A. Crommelin
Publisher: Springer Science & Business Media
Size: 49.43 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 544
View: 5782

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This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry. The Fourth Edition will completely update the previous edition, and will also include additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech.

Biophysical Chemistry PDF Download

Biophysical Chemistry PDF
Author: John T. Edsall
Publisher: Academic Press
Size: 25.62 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 716
View: 1833

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Biophysical Chemistry, Volume I: Thermodynamics, Electrostatics, and the Biological Significance of the Properties of Matter focuses on the biological aspects of the properties of matter, putting emphasis on the chemical elements, water and carbon dioxide, complex molecules, and proteins. The publication first elaborates on biochemistry and geochemistry, water and its biological significance, and the problems of protein structure. Discussions focus on the number of peptide chains in the molecule and nature of terminal groups, latent heat of fusion, characteristics of the amino acids derived from proteins, expansion of water in freezing, and the relative abundance of chemical elements in the universe. The text then takes a look at thermodynamics and the application to polar molecules and ionic solutions of electrostatics, including free energy of a charged sphere, image charges, salting-out effect, expressions for the change of fundamental thermodynamic functions, and chemical potentials. The book examines the conductivity of electrolytes, acid-base equilibria, and polybasic acids, bases, and ampholytes, including proteins. Topics include ionization of cysteine, isoelectric points of polyvalent ampholytes, hemoglobin, nature of acids and bases, measurement of conductivity, electrolytes as conductors, and the moving boundary method of determining transference numbers. The manuscript is a dependable reference for chemists and researchers interested in thermodynamics, electrostatics, and the biological value of the properties of matter.